Impact of bacterial lectin on functional activity of lymphocytes
Ponomareva, E.G.; Emel'ianova, N.V.; Nikitina, V.E.; Zakharova, N.B.
Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 2007(2): 60-65
2007
ISSN/ISBN: 0372-9311 PMID: 17523482 Document Number: 607385
Impact of Azospirillum brasilense Sp7 lectin with carbohydrate specificity to L-fucose on T- and B-lymphocytes production, activity of IL-1 alpha, and TNF-alpha was studied in vitro and compared with influence of red kidney bean phytohemagglutinin (PHA) on the same parameters. Increase of growth of T- and B-cells subpopulations has been shown that point to stimulatory effect of the bacterial lectin. Bacterial lectin of A.brasilense also increased synthesis of IL-1 alpha and TNF-alpha. It has been shown that the bacterial lectin has more pronounced stimulatory effect on functional activity of lymphocytes compared with PHA.