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Isolation and functional characterization of a mitogenic lectin from the marine sponge Cinachyrella alloclada

Atta, A.M.; Barral-Netto, M.; Peixinho, S.; Sousa-Atta, M.L.

Brazilian Journal of Medical and Biological Research 22(3): 379-385

1989

ISSN/ISBN: 0100-879X
PMID: 2804472
Document Number: 334401
1. A D-galactose-specific lectin was isolated from crude extracts of the marine sponge Cinachyrella alloclada by affinity chromatography on Sepharose 4B. 2. The lectin agglutinated human erythrocytes irrespective of their ABO group antigens. 3. Hemagglutination inhibition tests indicated that the lectin binds D-galactose or carbohydrates having a terminal nonreducing D-galactosyl group. 4. C. alloclada lectin was mitogenic for human peripheral blood lymphocytes when AB serum was omitted during the first 24 h of culture. 5. Human serum apparently contains substances which bind or inactivate this lectin.

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