+/-) -Gelliusines A and B, two diastereomeric brominated tris-indole alkaloids from a deep water new caledonian marine sponge (Gellius or Orina sp.
Bifulco, G.; Bruno, I.; Minale, L.; Riccio, R.; Calignano, A.; Debitus, C.
Journal of Natural Products 57(9): 1294-1299
1994
ISSN/ISBN: 0163-3864 PMID: 7798965 Document Number: 425099
Two new diastereomeric brominated tris-indole alkaloids occurring as enantiomeric pairs, (+-)-gelliusines A (1) and B (2), have been isolated from a deep water New Caledonian sponge (Gellius or Orina sp.), whose crude extract exhibited cytotoxicity against KB cells. Their structures were elucidated by spectroscopic methods including one- and two-dimensional nmr spectroscopy. The major compound, (+-) gelliusine A (1), which showed very weak cytotoxicity, proved to be active at the serotonin receptor.