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Histochemical demonstration of tetrahydrofolate dehydrogenase in human bone marrow: apparent enzymatic induction after administration of folic acid antagonists

Gerzeli, G.; Nano, R.; Marini, G.

Bollettino della Societa Italiana di Biologia Sperimentale 55(6): 590-596

1979

ISSN/ISBN: 0037-8771
PMID: 550890
Document Number: 142386
Folate antagonists interfere to a varying extent with the histochemical demonstration of tetrahydrofolate dehydrogenase. Some aspects of this interaction are investigated in normal hemopoietic cells of patients following antitumor treatment with methotrexate. In this situation the histochemically detectable activity of tetrahydrofolate dehydrogenase exceeds the control levels (apparent enzymatic induction). A protection of the enzyme-metabolite complex from degradation and diffusion might be effective for the changes in reaction intensity.

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Nano, R.; Gerzeli, G.; Gervaso, M.V. 1984: Tetrahydrofolate dehydrogenase in the bone marrow of rats experimentally treated with phenylhydrazine Cellular and Molecular Biology 30(2): 111-116
Ghizzi, A.; de Caro, L.; Bensi, L.; Berti, P. 1991: In vitro activity of folic acid on the proliferation dynamics of human bone marrow CFU-GM in propyphenazone-induced granulocytopenia Bollettino della Societa Italiana di Biologia Sperimentale 67(6): 553-560
Nano, R.; Gerzeli, G.; Gervaso, M.V.; De Piceis Polver, P.; Arisi, C. 1979: Histochemical pattern of tetrahydrofolate dehydrogenase in hemopoietic cells following folate antagonist treatment in vivo Cellular and Molecular Biology Including Cyto-Enzymology 24(3): 191-197
Gantner, J.; Herold, H.; Heierli, B.; Lübin, H. 1973: Slight bone marrow abnormalities in relation to folic acid and vitamin B 12 Nouvelle Revue Francaise d'Hematologie 13(3): 345-350
Gassmann, W.; von Kolszynski, M.; Wottge, H.U.; Müller-Ruchholtz, W. 1987: Demonstration of strong classic immune reactivity after total-body irradiation for bone marrow transplantation. Implications for human T-depleted bone marrow transplantation Transplantation Proceedings 19(1 Part 3): 2687-2688
Zaritskiĭ, A.I.; Kazhdan, I.I.; Kulik, M.A.; Lisovskaia, V.A.; Filev, L.V. 1984: Colony-forming capacity of fibroblastic cells--bone marrow precursors--in patients with B12- and folic acid-deficiency anemias and liver cirrhosis with hypersplenism Gematologiia i Transfuziologiia 29(4): 15-17
Bandurko, L.N. 1986: Histochemical demonstration of enzymatic activity in the mucous layer of the internal organs Arkhiv Anatomii Gistologii i Embriologii 91(11): 71-73
Heinzl, S. 2004: Folic acid antagonists pemetrexed Medizinische Monatsschrift für Pharmazeuten 27(7): 220-222
Schmidt, W.; Gabler, W.; Wendler, D. 1970: Quantitative evaluation of the histochemical succinate dehydrogenase demonstration and its dependence upon different reaction conditions Acta Histochemica 37(2): 250-258
Randazzo, S.D.; Mirone, A.; Giardina, A.; Guarneri, B. 1972: On special methods of use of folic acid antagonists in psoriasis Giornale Italiano di Dermatolotia. Minerva Dermatologica 47(4): 151-155
Loo, T.L.; Johns, D.G.; Farquhar, D. 1973: Recent advances in the biochemical pharmacology of folic acid antagonists Transplantation Proceedings 5(3): 1161-1165
Szulc, B.; Inglot, A.D.; Szulc, Z.; Młochowski, J. 1985: Competition of sodium salt of 9-oxo-10-acridineacetic acid with analogs during induction of interferon in the mouse bone marrow-derived macrophages Archivum Immunologiae et Therapiae Experimentalis 33(2): 287-297
Reich, E.W.; Cox, R.P.; Becker, M.H.; Genieser, N.B.; McCarthy, J.G.; Converse, J.M. 1978: Recognition in adult patients of malformations induced by folic-acid antagonists Birth Defects Original Article Series 14(6b): 139-160
Oniceşcu, D.; Diculescu, I. 1979: Histochemical study on the dihydrofolatereductase and folic acid in mammalian brain cortex Journal für Hirnforschung 20(6): 663-665
Fong, S.; Vaughan, J.H.; Tsoukas, C.D.; Carson, D.A. 1982: Selective induction of autoantibody secretion in human bone marrow by Epstein Barr virus Journal of Immunology 129(5): 1941-1945
Champel, V.; Radal, M.; Moulin-Vallez, M.; Jonville-Béra, A.P.; Autret-Leca, E. 1999: Should folic acid be given to women treated with valproic acid and/or carbamazepine? Folic acid and pregnancy in epilepsy Revue Neurologique (Paris) 155(3): 220-224
Lazo, J.S.; Chen, D.L.; Gallicchio, V.S.; Hait, W.N. 1986: Increased lethality of calmodulin antagonists and bleomycin to human bone marrow and bleomycin-resistant malignant cells Cancer Research 46(5): 2236-2240
Marsh, J.C. 1982: Comparative effects of methotrexate, two nonclassic folic acid antagonists, and cytarabine on hematopoietic precursor cells Cancer Treatment Reports 66(3): 499-504
Lindholm, T.S.; Urist, M.R. 1980: A quantitative analysis of new bone formation by induction in compositive grafts of bone marrow and bone matrix Clinical Orthopaedics and Related Research 150: 288-300
Kihlberg, R. 1995: Folic acid prevents neural tube defects. All women of fertile age should increase their intake of folic acid Lakartidningen 92(6): 508-512