Recognition in adult patients of malformations induced by folic-acid antagonists
Reich, E.W.; Cox, R.P.; Becker, M.H.; Genieser, N.B.; McCarthy, J.G.; Converse, J.M.
Birth Defects Original Article Series 14(6b): 139-160
1978
ISSN/ISBN: 0547-6844 PMID: 728558 Document Number: 125588
Three patients are reported, two of whom had mothers who revealed ingestion of abortifacient drugs during pregnancy. All patients resemble one another and those described earlier with malformations that were probably either aminopterin- or methotrexate-induced. It is likely that Patients I and II have abnormalities associated with the teratogenic action of these folic-acid antagonists. The etiology of Patient III's defects remains uncertain.