Mechanism of the effect of immobilized noradrenaline on the contact phase of blood coagulation
Zubairov, D.M.; Popova, L.G.; Krinskaia, A.V.; Egorova, T.P.; Fedorova, N.V.
Voprosy Meditsinskoi Khimii 25(5): 544-548
1979
ISSN/ISBN: 0042-8809 PMID: 494537 Document Number: 141141
A deficiency in the contact phase of blood coagulation, depending on the specific isolation of Fletcher's factor (prekallikreins) from blood plasma, was observed after chromatography of blood plasma on a column with noradrenaline-Sepharose. Activation of kalliklein and dekinination of high-molecular kininogene occurred after the interaction between proenzymes of contact phase of blood coagulation (factor XII, prekallikreins, high-molecular kininogene).