Study of the mechanism of adsorption and activation of enzymes of the contact phase of blood coagulation
Adadullina, Z.Z.; Popova, L.G.
Voprosy Meditsinskoi Khimii 22(3): 356-360
1976
ISSN/ISBN: 0042-8809 PMID: 829007 Document Number: 102810
Desorption of enzymes, participating in contact phase of blood coagulation, from silica surface was studied under effect of increased ion strength, in presence of urea, EDTA and surface-active substances. All these agents varied in their capacity to decrease the enzymes activity and to cause the desorption of contact factors. Ionic and hydrogen bonds were shown to carry out the leading role in adsorption of factor XII and in the initiation of the contact phase of blood coagulation.