Capacity of activation of so-called deficient factors in hereditary blood coagulation disorders
Mingers, A.M.
Fortschritte der Medizin 94(30): 1723-1725
1976
ISSN/ISBN: 0015-8178 PMID: 1086815 Document Number: 104479
By factor-specific exchange-experiments it was proved that the lack of factor VIII activity in hemophilia A is not caused by an incapacity of activation or even lack of the factor, but by a defect of the pertaining activator resp. activator system. The same goes for factor IX in hemophilia B as well as factors VII, IX and X in family defect of the prothrombin-complex. In contrast, inactivity in the von Willebrand-Jünrgens-disease is obviously caused by a genuine lack of factor VIII.