Effects of milbemycin on adult Toxocara canis in dogs with experimentally induced infection
Bowman, D.D.; Parsons, J.C.; Grieve, R.B.; Hepler, D.I.
American Journal of Veterinary Research 49(11): 1986-1989
1988
ISSN/ISBN: 0002-9645 PMID: 3247924 Document Number: 135
To determine the efficacy of a formulation of milbemycins in treating patent infection with Toxocara canis, 8 male and 7 female, 10-week-old, ascarid-free Beagles each were given 125 embryonated eggs of T canis. All dogs developed patent infection within 56 days. On postinfection day 70, the dogs were assigned to 1 of 3 groups of 5 dogs each; members of 1 group were given a placebo, while dogs of the other 2 groups were given either 5.68 or 34.08 mg of the milbemycin formulation, respectively. In both groups of dogs given the drug, the number of eggs passed per gram of feces decreased precipitously. However, a few eggs still were found in the feces of several dogs of each group on the day of necropsy (postinfection day 75). Worms or fragments of worms were passed by the treated dogs from the day of treatment until the day on which necropsy was performed; however, most worms were passed during the first 2 days after treatment. At necropsy, only dogs of the control group were found to harbor adult T canis.
Document emailed within 1 workday
