Contribution of prostaglandins to the vasodepressor effect of dopamine in the rat
Chevillard, C.; Mathieu, M.N.; Barjon, P.
Journal of Pharmacy and Pharmacology 30(5): 329-330
1978
ISSN/ISBN: 0022-3573 PMID: 26756 Document Number: 133962
The release by dopamine of vasodepressor agents, such as endogenous prostaglandins (PG) could explain the depressor effect of the amine, since PG, and particularly PGA1, mimic some effects of dopamine. The effect of indomethacin, a potent inhibitor of PG synthesis and release, on the vasodepressor action of dopamine was studied in the anesthetized rat pretreated by phenoxybenzamine. If the depressor response to dopamine is mediated by PG, then inhibition of PG synthesis and release may attenuate or abolish the response of the vascular bed to the amine. Arachidonic acid, PGE1 and sodium nitroprusside also produced hypotensive effects. Indomethacin did not affect the depressor action of sodium nitroprusside, rather it enhanced the hypotensive effect of PGE1 and fully reduced the vasodepressor action induced by arachidonic acid. The data support the role of PG in the systemic depressor response to dopamine in the anesthetized rat.