Effect of cobalt chloride on polypeptide synthesis in Escherichia coli K12

Guha, C.; Mookerjee, A.

Indian Journal of Experimental Biology 16(8): 862-864

1978


ISSN/ISBN: 0019-5189
PMID: 361550
Document Number: 130244
Co2+ inhibited cell free protein synthesis directed by natural mRNA. However, when synthetic polynucleotides like Poly U and Poly GU were used as templates, there was no inhibition of translation in Co2+ treated cell extracts. In vivo, the polypeptide chain elongation rate declined to half during Co2+ treatment.

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