An ultrastructural study of the epidermis in hyperkeratosis lenticularis perstans
Ikai, K.; Murai, T.; Oguchi, M.; Takigawa, M.; Komura, J.; Ofuji, S.
Acta Dermato-Venereologica 58(4): 363-365
1978
ISSN/ISBN: 0001-5555 PMID: 82336 Document Number: 129836
A 60-year-old Japanese man contracted hyperkeratosis lenticularis perstans (Flegel). Biopsy specimens of the keratotic papules on the dorsa of the feet were studied with electron microscopy. An increase in the number of membrane coating granules, keratohyalin granules and tonofilaments was the most prominent feature of the keratinocytes underlying the keratotic papule. However, in the area just above the cone-shaped dermal infiltration, membrane coating granules were absent and keratohyalin granules and tonofilaments were poorly developed.