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Study of proliferative activity and nucleolar organizers in the epidermis of patients with psoriasis

Tereshin, K.Ia.; Tsygankov, V.I.; Fleĭshman, M.Iu.; Mel'nikova, N.P.

Klinicheskaia Laboratornaia Diagnostika 2002(1): 39-40

2002

ISSN/ISBN: 0869-2084
PMID: 11855340
Document Number: 547408
Time course of proliferative activity of the epidermis was studied in patients with psoriasis by analysis of histoautoradiography data and evaluation of the activity of the ribosome nucleolar organizers. The findings indicate that the proliferative activity is increased in psoriasis. The activity of the ribosome nucleolar organizers increases during the progressive stage of psoriasis and notably decreases during the stationary stage, while during regressive stage this activity is the same as in apparently normal (after resolution of eruptions) skin of psoriasis patients. The results indicate that evaluation of the activity of nucleolar organizers in psoriatic elements can serve as an important additional test in laboratory diagnosis of psoriasis stages.

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