Lymphocyte-epidermis interactions in malignant epidermotropic lymphomas: I. Ultrastructural aspects
Schmitt, D.; Thivolet, J.
Acta Dermato-Venereologica 60(1): 1-11
1980
ISSN/ISBN: 0001-5555 PMID: 6153827 Document Number: 167509
The interactions between lymphocytes, Langerhans cells and keratinocytes are described by EM in cutaneous lesions of malignant epidermotropic lymphomas (mycosis fungoides and Sezary's syndrome). Various contacts are observed between the different cells. During the degenerating process of keratinocytes, Langerhans cells disappear and histiocytic cells are bound to necrosing epidermal cells. The immunological process of Pautrier microabscess formation is discussed by comparison with ultrastructural aspects of cutaneous lesions of graft vs. host reaction in man.