Methods for simultaneous recording of pharmacodynamic and toxic effects on interior sensitive receptors, respiration and cardiac-circulatory system of guinea pigs
Kilian, U.; Müller, E.; Dittmann, E.C.; Hamacher, J.
Arzneimittel-Forschung 28(10): 1699-1708
1978
ISSN/ISBN: 0004-4172 PMID: 582672 Document Number: 129653
A method for simultaneous, continuous registration of pharmacodynamic and toxic effects, resp., on pulmonary-stretch receptors, on respiration and on hemodynamics in guinea pigs is described. The following parameters are recorded synchronously by a multi-track recorder: 1. The afferences in the cervical n. vagus; its electrical integration is employed for measuring the total intensity and the ex- and the inhalation intensity, resp., of the afferences; 2. the pneumatogram for measuring the maximum velocity of air flow, duration of the breath phase and parts thereof (in-, and exhalation and postexpiratory pause), and the respiration rate; 3. the diastolic and systolic blood pressure during in- and exhalation and postexpiratory pause; 4. the electrocardiogram (ECG). The normal distribution of the initial values is examined and discussed. Further the initial values measured in three series of experiments are discussed and compared: mono-vagotomy/spontaneous respiration, bivagotomy/spontaneous respiration and artificial respiration/monovagotomy. The results are compared with some experimental and clinical findings from literature.