Pathogenesis of experimental pulmonary paragonimiasis in cats
Hoover, E.A.; Dubey, J.P.
American Journal of Veterinary Research 39(11): 1827-1832
1978
ISSN/ISBN: 0002-9645 PMID: 736340 Document Number: 129417
Twenty SPF cats were inoculated orally with metacercariae of Paragonimus kellicotti and necropsied between 1 and 263 days later. The immature Paragonimus flukes excysted in the intestine, penetrated the intestinal wall, and migrated from the peritoneal cavity through the diaphragm to the pleural surface of lungs by 5 to 23 days after inoculation. This migration resulted in multifocal eosinophilic peritonitis and myositis. The flukes entered the lung by penetration of the pleura, which resulted in multifocal pleural haemorrhage and eosinophilic pleuritis. Immature flukes developed in the subpleural alveolar tissue surrounded by intense eosinophilic and neutrophilic inflammation. Communications developed between the fluke-containing subpleural cavities and adjacent bronchioles by 39 days after inoculation and ova from the sexually mature flukes entered the bronchioles. From 55 to 263 days after inoculation, other prominent pulmonary lesions were peribronchiolar infiltration of lymphocytes and plasma cells, hyperplasia of bronchioles and peribronchiolar glands, and chronic active eosinophilic granulomatous pneumonia associated with degenerating Paragonimus ova in the alveolar tissue adjacent to cysts. The interior surface of the fluke-containing cysts became partially epithelialized by cells from communicating bronchioles.