Antimalarial 6-aminoquinolines. VII. 2- and 4-Alkoxy derivatives of 6- (4-diethylamino-1-methylbutylamino) -5,8-dimethoxyquinoline
Nickel, P.; Barnickel, H.; Preissinger, L.; Fink, E.; Dann, O.
Arzneimittel-Forschung 28(3): 367-372
1978
ISSN/ISBN: 0004-4172 PMID: 580743 Document Number: 129282
19 derivatives, 10 a--t, of 6-(4-diethylamino-1-methylbutylamino)-5,8-dimethoxyquinoline (1a) with alkoxy-, hydroxy-, and methylmercapto substituents in 4- and/or 2-position were synthesized with the aim of studying the influence of these substituents on antimalarial activity and toxicity of 1a. The alkoxy derivatives of 1a are highly active against P. vinckei (mouse). The 2- and 4-hydroxy derivatives, 10 l and 10 m, are inactive.