The effect of 12-alkoxy modification on the in vitro antileukaemic activity of N-methyl 2,3,8,9-tetramethoxybenzo[c]phenanthridinium salts
Mackay, S.P.; Comoe, L.; Desoize, B.; Duval, O.; Jardillier, J.C.; Waigh, R.D.
Anti-Cancer Drug Design 13(7): 797-813
1998
ISSN/ISBN: 0266-9536 PMID: 9807163 Document Number: 490019
Some members of a series of 12-alkyloxy benzo(c)phenanthridines are potent inhibitors of the growth of P388 tumour cells in vitro, with a strong dependence on the nature of the 12-substituent. Analogues with a quaternary nitrogen in the side chain bind strongly to DNA but are less active against the tumour cells. The multi-drug-resistant cell line Pr8/22 shows less sensitivity to the new compounds. K562 Human leukaemia cells undergo differentiation in the presence of the benzo(c)phenanthridine derivatives with a structure-activity relationship which does not correlate well with potency against the P388 cell line.