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The toxicity of some halomethanes in mice

Bowman, F.J.; Borzelleca, J.F.; Munson, A.E.

Toxicology and Applied Pharmacology 44(1): 213-215

1978

ISSN/ISBN: 0041-008X
PMID: 675691
Document Number: 128959
The acute toxicity of trichloromethane, bromodichloromethane, dibromochloromethane and tribromomethane was studied in mice following administration by gastric gavage. Gross pathological changes included fatty infiltration of the liver and signs of hemorrhage in the kidneys, adrenals, lungs and brain. Median lethal doses (LD50) were also calculated. The males were more sensitive to each of the compounds than females.

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