Modification of the toxicity of acetylcholine by prior atropinization in mice
Sanan, S.; Goel, N.K.
Indian Journal of Physiology and Pharmacology 22(1): 98-100
1978
ISSN/ISBN: 0019-5499 PMID: 680946 Document Number: 130883
The potentiation of acetylcholine (Ach) toxicity in mice with prior atropinization was tested. The experiments were carried out with three doses of 200 mg, 300 mg, and 400 mg/kg of Ach administered ip. Prior atropinization was observed to potentiate the Ach toxicity at all dose levels of atropine except the highest in the group that received Ach 200 mg/kg and the results were variable in the other two groups.