Enzymes, inhibitors and emphysema
Hutchison, D.C.
Bulletin Europeen de Physiopathologie Respiratoire 14(1): 1-10
1978
ISSN/ISBN: 0395-3890 PMID: 752390 Document Number: 128000
Hereditary .alpha.1-antitrypsin deficiency phenotypes are correlated to the incidence of pulmonary diseases including emphysema, chronic bronchitis, asthma, cryptogenic fibrosing alveolitis and pneumonia or neonatal hepatitis. Phenotypic analysis is performed by starch gel electrophoresis. Tobacco smoking and a genetic predisposition are cited as factors for the pathogenesis of enzyme associated diseases. Administration of Escherichia coli endotoxin to pulmonary leukocytes is employed to evaluate antitrypsin leukoprotease activity.