Thyroid hormone formation in ectopic thyroid gland. A case study
Matsumoto, T.; Ogata, E.; Yamamoto, M.; Aiyoshi, Y.; Nagataki, S.
Acta Endocrinologica 87(4): 728-733
1978
ISSN/ISBN: 0001-5598 PMID: 580519 Document Number: 126987
Several steps of thyroid hormogenesis were studied on a subhyoid ectopic thyroid tissue in a case of compensated hypothyroidism with simultaneous sublingual and subhyoid ectopic thyroid. The patient, a 19 yr old girl, had normal values for serum T4 level. The thyroidal 131I uptake was elevated both at 3 h and 24 h after oral 131I intake. No significant discharge of radioiodine was observed after perchlorate load. On the thyroid biopsy specimen, peroxidase activity was normal by both assays of guaiacol oxidizing and iodinating activity. Thyroglobulin was 19S and was normally iodinated in vitro with peroxidase. I content of thyroglobulin was within the normal range. The mean percentage distribution of 131I administered 7 days prior to the biopsy showed no significant difference from the normal pattern. No specific defects in thyroid hormogenesis were detected in this case. Abnormalities in thyroid function in this case are apparently mainly due to insufficient functioning mass in the ectopic thyroid.