Enzymatic and immunologic study of the role of the thyroid hormone in the formation of the internal mitochondrial membrane during postnatal development of the rat

Coquard, C.; Latruffe, N.; Duroc, R.; Gaudemer, Y.

Comptes Rendus des Seances de la Societe de Biologie et de ses Filiales 178(4): 414-420

1984


ISSN/ISBN: 0037-9026
PMID: 6241015
Document Number: 222620
Hypothyroidism induces an increase of liver D-beta-hydroxybutyrate dehydrogenase activity. Injection of thyroid hormone reverses the phenomena. The use of monospecific antibody raised against the purified enzyme indicates that there was not an increase of apoenzyme biosynthesis. The thyroid hormone negative control is due to a metabolism alteration of the membrane phospholipids which are directly involved in the apoenzyme activity. The highest difference is observed with 20 days old rats. Opposite effects were obtained on succinate cytochrome c reductase.

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