Morphometric analysis of lymphoid organs in the hypophysectomized rat
Tosi, P.; Cintorino, M.; Luzi, P.; Lungarella, G.
Bollettino della Societa Italiana di Biologia Sperimentale 54(19): 1893-1899
1978
ISSN/ISBN: 0037-8771 PMID: 753277 Document Number: 126598
The effects of hypophysectomy on the lymphoid organs were evaluated in Wistar rats by morphometrical analysis: after 30 days the percentage of thymus cortical area and lymph node paracortical areas were reduced. In the thymus cortex, signs of orthological involution (e.c.: nodular cortex) appeared. A significant enlargement of lymph node cortical areas, containing a high number of germinal centers with degenerative changes, could be seen. These findings suggest a significant trophic action of hypophysis on thymus and, perhaps, an impaired lymph node antibody mediated response due to the loss of T-B cooperation.