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Carcinogenic activity of Symphytum officinale

Hirono, I.; Mori, H.; Haga, M.

Journal of the National Cancer Institute 61(3): 865-869

1978

ISSN/ISBN: 0027-8874
PMID: 278864
Document Number: 126231
The carcinogenicity of Symphytum officinale L., Russian comfrey, used as a green vegetable or tonic, was studied in inbred ACI rats. Three groups of 19--28 rats each were fed comfrey leaves for 480--600 days; four additional groups of 15--24 rats were fed comfrey roots for varying lengths of time. A control group was given a normal diet. Hepatocellular adenomas were induced in all experimental groups that received the diets containing comfrey roots and leaves. Hemangioendothelial sarcoma of the liver was infrequently induced.

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