Carcinogenic activity of dicyclohexylamine and of its nitrite salts
Pliss, G.V.
Voprosy Onkologii 4(6): 659-669
1958
ISSN/ISBN: 0507-3758 PMID: 13636114 Document Number: 8421
The carcinogenic activity of of cyclohexylamine (CHA); dicycloliexylamine (DiCHA and dicyclohexylaminenitrite (DiCHAN),was investigated on 186 albino rats and' 111 mice .o£ the low cancer, strain "D". These compounds were being administered to the animals per os and subcutaneously for the period of about 12 months. No tumours were obtained after 23 months in rats fed on CHA. Sarcomas on the site of the injection of DiCHA were induced in 4 mice after 12-16 months following the experiment. The same compound administered perorally caused omental and hepatic tumours in 2 rats. Visceral tumours were observed in 13 rats and mice which were injected DiCHAN or fed on it. The toxicity of all these compounds was estimated simultaneously.
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