Treatment of cervical carcinoma with adriamycin combined with methotrexate

Papavasiliou, C.; Pappas, J.; Aravantinos, D.; Kaskarelis, D.; Papavasiliou, C; Pappas, J; Aravantinos, D; Kaskarelis, D

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Treatment of cervical carcinoma with adriamycin combined with methotrexate

Papavasiliou, C.; Pappas, J.; Aravantinos, D.; Kaskarelis, D.

Cancer Treatment Reports 62(9): 1387-1388

1978

ISSN/ISBN: 0361-5960

PMID: 688283

Document Number: 125855

Several series of patients with carcinoma of the uterine cervix were treated using various chemotherapeutic agents. Combined therapy gave superior results in comparison to single agents. Adriamycin was given at a dose of 50 mg/m2 i.v. on day 1 and methotrexate was given at a dose of 20 mg/m2 on days 1 and 8. On day 22, the scheme was repeated. No patient had a complete response. A 50% reduction in tumor size was noted in 7 patients (20%). Among 16 patients with pain, 14 had partial pain relief. Drug toxicity was not severe.