Combined use of local and systemic radiomodifiers as a new modality of cervical carcinoma therapy
Neklasova, N.Iu.; Zharinov, G.M.; Vinokurov, V.L.; Skrynditsa, G.M.
Voprosy Onkologii 52(5): 560-564
2006
ISSN/ISBN: 0507-3758 PMID: 17168367 Document Number: 601955
Central Research Institute of Roentgeno-Radiology, the Ministry of Health of the RF, St.Petersburg; Regional Dispensary, Chernovtsy, UkraineA cooperative study included 643 cervical carcinoma patients (stage II-III). Radiotherapy used such local and systemic radiomodifiers as DMSO-dissolved metronidazole,which inhibited allopurinol DNA reparations, and dipyridamol, an inductor of interferon synthesis. A 13-15% rise in survival matched the results of combined treatment for cervical carcinoma, yet the simplicity of operation, accessibility, high efficiency and stability of results of our modality made it quite competitive in therapy of the disease.