Irinotecan in preoperative combined-modality therapy for locally advanced rectal cancer
Mitchell, E.P.
Oncology 14(12 Suppl. 14): 56-59
2000
ISSN/ISBN: 0890-9091 PMID: 11200151 Document Number: 524477
Irinotecan (CPT-11, Camptosar) is a semisynthetic water-soluble derivative of the plant alkaloid camptothecin. This review will focus on the potential use of irinotecan in combination with fluorouracil (5-FU) in the preoperative combined-modality treatment of advanced rectal cancer. The laboratory studies that define the mechanism of fluoropyrimidine- and camptothecin-mediated radiosensitization are discussed, and the rationale for combined-modality therapy using radiation with 5-FU and irinotecan is presented.
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