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Preoperative chemoradiation for locally advanced rectal cancer with capecitabine 2,000 mg/m2/day

Veerasarn, V.; Boonnuch, W.; Chinswangwatanakul, V.; Lohsiriwat, D.; Mahamadsolaeh, P.

Journal of the Medical Association of Thailand 91(10): 1583-1588

2008

ISSN/ISBN: 0125-2208
PMID: 18972903
Document Number: 14223
Evaluate the efficacy and the tolerability of preoperative chemoradiation with high dose Capecitabine. Fifteen patients with locally advanced resectable rectal cancer were treated with Capecitabine 2,000 mg/m2/day, orally 7 days/week concurrent with whole pelvic irradiation 45 Gy in 25 fractions/5 weeks. Patients underwent surgery in the following 4-6 weeks. After complete treatment, 11 patients (73%) underwent surgery. Ten patients (66%) had sphincter preservative surgery; three of them had primary tumors located in the lower rectum. Five patients had grade 2 and one patient had grade 3 diarrhea. No grade 4 toxicity was reported. Preoperative Capecitabine 2,000 mg/m2/day concurrent with whole pelvic irradiation were effective and well tolerated The potential dose limiting toxicity effect was the diarrhea.

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Preoperative chemoradiation for locally advanced rectal cancer with capecitabine 2,000 mg/m2/day

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