Preoperative chemoradiotherapy in locally advanced rectal cancer: Ramathibodi experience
Sirachainan, E.; Sumboonnanonda, K.; Dangprasert, S.; Panvichian, R.; Sirisinha, T.; Dhanachai, M.; Pairachvet, V.; Kraiphibul, P.; Ratanatharathorn, V.
Journal of the Medical Association of Thailand 88(2): 162-167
2005
ISSN/ISBN: 0125-2208 PMID: 15962665 Document Number: 2435
A retrospective study of the preoperative chemoradiotherapy in locally advanced rectal cancer performed at Ramathibodi Hospital. The median age of twelve patients was 52 years. The tumor locations (upper-, mid-, lower rectum) were 25%, 50% and 25%, respectively. Eleven patients had clinical stage III disease. All received concurrent 5-FU-based chemoradiotherapy followed by surgery (if resectable) and chemotherapy. The most common toxicity of preoperative treatment was gr.1-2 diarrhea (58.3%). The response rate was 41.7%. Five patients (41.7%) underwent sphincter-sparing surgery. Four patients underwent AP resection. Twenty-five percent achieved pathological complete response. Pathological downstaging occurred in 33.3%. The remaining three patients had unresectable disease. With the median follow up of 13 months, five patients had progressive disease and one has expired The local failure rate was 16.7%. The one-year recurrence-free survival was 75%. The authors conclude that preoperative chemoradiotherapy is an effective treatment with favorable outcome in locally advanced rectal cancer
Document emailed within 1 workday
