Cis-platinum, doxorubicin, and methotrexate treatment for recurrent cervical cancer
Wheelock, J.B.; Krebs, H.B.; Goplerud, D.R.; Myers, M.
Obstetrics and Gynecology 66(3): 410-412
1985
ISSN/ISBN: 0029-7844 PMID: 4040622 Document Number: 247177
A combination of cis-platinum, doxorubicin (Adriamycin), and methotrexate was used to treat 28 patients with recurrent cervical cancer. Seven patients achieved a partial response with a median duration of ten months. Two patients achieved a complete response with a median duration of 14 months. The overall response rate was 32%. Ten patients with stable disease had a median progression-free interval of 4.5 months. Toxicity was acceptable.
Document emailed within 1 workday
Related Documents
Lovecchio, J.L.; Averette, H.E.; Lichtinger, M.; Townsend, P.A.; Girtanner, R.W.; Fenton, A.N. 1984: Treatment of advanced or recurrent endometrial adenocarcinoma with cyclophosphamide, doxorubicin, cis-Platinum, and megestrol acetate Obstetrics and Gynecology 63(4): 557-560Tropé, C.; Kristensen, G.; Kisic, J.; Kaern, J. 2001: Long-term results from a phase II study of paclitaxel combined with doxorubicin in recurrent platinum refractory ovarian cancer European Journal of Gynaecological Oncology 22(3): 223-227
Bilgi, O.; Karagoz, B.; Alacacioglu, A.; Ozgun, A.; Tuncel, T.; Gokhan-Kandemir, E. 2010: Irinotecan and cisplatin vs. cyclophosphamide, doxorubicin, and vincristine as second-line treatment after platinum and etoposide in small-cell lung cancer Journal of BUON: Official Journal of the Balkan Union of Oncology 15(2): 395
Baroncelli, G.; La Monica, M.M. 1992: Epirubicin, methotrexate and bleomycin (EMB) in the treatment of recurrent epidermoid cancer of the head and neck Tumori 78(5): 330-332
Vogl, S.E.; Pagano, M.; Kaplan, B.H.; Einhorn, N.; Arseneau, J.; Moukhtar, M.; Greenwald, E. 1980: Combination chemotherapy of advanced ovarian cancer with hexamethylmelamine, cis-Platinum, and doxorubicin after failure of prior therapy Obstetrics and Gynecology 56(5): 635-640
Pinheiro, W.; Pereira, A.K.C.; Soares, J.M.; Baracat, E.C. 2011: Is the combination of mitomycin C, bleomycin and methotrexate effective as a neoadjuvant treatment for cervical cancer in women? European Journal of Gynaecological Oncology 32(1): 37-39
Wachters, F.M.; Van Der Graaf, W.T.A.; Groen, H.J.M. 2004: Cardiotoxicity in advanced non-small cell lung cancer patients treated with platinum and non-platinum based combinations as first-line treatment Anticancer Research 24(3b): 2079-2083
Mitsugi, K.; Yasutake, T.; Etoh, T.; Ishimaru, T.; Ueda, A.; Nakano, S.; Niho, Y. 1993: Successful treatment of recurrent multiple lung metastasis from colon cancer with combination chemotherapy using methotrexate, 5-fluorouracil, and high-dose leucovorin: a case report Gan to Kagaku Ryoho. Cancer and ChemoTherapy 20(15): 2387-2390
Jones, A.L.; Holborn, J.; Ashley, S.; Smith, I.E. 1991: Effective new low toxicity chemotherapy with carboplatin, vinblastine and methotrexate for small cell lung cancer: a randomised trial against doxorubicin, cyclophosphamide and etoposide European Journal of Cancer 27(7): 866-870
Tan, S.J.; Juan, Y.H.; Fu, P.T.; Yu, M.H.; Lai, H.C. 2010: Chemotherapy with low-dose bevacizumab and carboplatin in the treatment of a patient with recurrent cervical cancer European Journal of Gynaecological Oncology 31(3): 350-353
Matoda, M.; Omatsu, K.; Yamamoto, A.; Nomura, H.; Tanigawa, T.; Kawamata, Y.; Kato, K.; Umayahara, K.; Takeshima, N. 2014: Importance of platinum-free interval in second-line chemotherapy for advanced or recurrent endometrial cancer European Journal of Gynaecological Oncology 35(3): 224-229
Katsumata, K.; Yamamoto, K.; Ashizawa, T.; Sumi, T.; Yamashita, S.; Nagashima, K.; Murohashi, T.; Majima, T.; Mori, M.; Takahashi, S.; Koyanagi, Y. 2000: Two cases of recurrent gastric cancer for which combination chemotherapy with pirarubicin, cis-platinum and 5-fluorouracil were markedly effective Gan to Kagaku Ryoho. Cancer and ChemoTherapy 27(1): 113-116
Watari, H.; Hosaka, M.; Mitamura, T.; Moriwaki, M.; Ohba, Y.; Todo, Y.; Takeda, M.; Ebina, Y.; Sakuragi, N. 2008: Weekly paclitaxel/5-fluorouracil followed by platinum retreatment for patients with recurrent ovarian cancer: a single institution experience European Journal of Gynaecological Oncology 29(6): 573-577
Curry, S.L.; Blessing, J.A.; Disaia, P.J.; Soper, J.T.; Twiggs, L.B. 1989: A prospective randomized comparison of methotrexate, dactinomycin, and chlorambucil versus methotrexate, dactinomycin, cyclophosphamide, doxorubicin, melphalan, hydroxyurea, and vincristine in "poor prognosis" metastatic gestational trophoblastic disease: a Gynecologic Oncology Group study Obstetrics and Gynecology 73(3 Pt 1): 357-362
Kagabu, T.; Izutsu, T.; Yoshizumi, N.; Sato, K.; Nishiya, I. 1985: Flow cytometric analysis of tumor cells during intra-arterial cis-platinum therapy of cervical cancer Rinsho Byori. Japanese Journal of Clinical Pathology 33(12): 1361-1366
Shimizu, Y.; Nakayama, K.; Seimiya, Y.; Yamakawa, Y.; Koi, S.; Yokosuka, K.; Teshima, H.; Chen, J.T.; Fujimoto, I.; Yamauchi, K. 1991: Treatment of advanced or recurrent cervical cancer by a new BOMP regimen consisting of bleomycin, vincristine, mitomycin-C, and low-dose consecutive cisplatin Nihon Sanka Fujinka Gakkai Zasshi 43(5): 549-556
Mori, A.; Hirose, T.; Tamura, A.; Kusaka, K.; Matsui, H.; Ohta, K. 2016: Evaluation of the Efficacy and Safety of Platinum Doublet Re-Challenge Chemotherapy in Patients with Recurrent Advanced Non-Small Cell Lung Cancer Gan to Kagaku Ryoho. Cancer and ChemoTherapy 43(6): 723-726
Platt, S.L.; Patel, A.; Humphrey, P.J.; Al-Booz, H.; Bailey, J. 2019: Completion surgery after chemoradiotherapy for cervical cancer - is there a role? UK Cancer Centre experience of hysterectomy post chemo-radiotherapy treatment for cervical cancer Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology 39(1): 68-73
Jeremiç, K.; Stefanović, A.; Milincić, N.; Mitrović, M.; Jeremić, J.; Mircić, A. 2011: Intestinal surgery and surgery of urinary tract in treatment of recurrent cervical cancer--case report European Journal of Gynaecological Oncology 32(4): 460-462
Ota, K.; Oguma, T.; Shimamura, K. 1994: Pharmacokinetics of platinum in cancer patients following intravenous infusion of cis-diammine(glycolato)platinum, 254-S Anticancer Research 14(3b): 1383-1387