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Methylglyoxal bis (cyclopentylamidinohydrazone) (MGBCP) : antitumor effect against human osteosarcoma cells and combined effect with methotrexate, adriamycin and 4-hydroperoxyifosfamide

Sonoda, J.; Hibasami, H.; Yamada, H.; Fujinami, S.; Nakashima, K.; Ogihara, Y.

Anticancer Research 15(3): 907-909

1995

ISSN/ISBN: 0250-7005
PMID: 7645980
Document Number: 449079
The antitumor effect of a polyamine biosynthetic pathway inhibitor methylglyoxal bis(cyclopentylamidinohydrazone) (MGBCP) on human osteosarcoma cell lines such as KHOS-240S, MG-63 and G-292 cells, and its effect in combination with anticancer drugs such as methotrexate (MTX), adriamycin (ADM) and 4-hydroperoxyfosfamide (HIFO) have been investigated. The growth of these cultured osteosarcoma cells was inhibited by MGBCP in a dose-dependent manner. Spermidine and spermine levels were dose-dependently depressed in these MGBCP-treated osteosarcoma cells. The antitumor effect of MGBCP was additively potentiated by combined treatment with MTX, ADM and HIFO, respectively.

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Hibasami, H.; Takaji, S.; Murata, T.; Nakashima, K. 1991: Cepharanthine potentiates the antitumor effect of methylglyoxal bis (cyclopentylamidinohydrazone) on human leukemia cells Anticancer Research 11(4): 1543-1547
Konno, H.; Suzuki, H.; Tadakuma, T.; Kumai, K.; Yasuda, T.; Kubota, T.; Ohta, S.; Nagaike, K.; Hosokawa, S.; Ishibiki, K. 1987: Antitumor effect of adriamycin entrapped in liposomes conjugated with anti-human alpha-fetoprotein monoclonal antibody Cancer Research 47(16): 4471-4477
Ghetie, M.A.; Richardson, J.; Tucker, T.; Jones, D.; Uhr, J.W.; Vitetta, E.S. 1991: Antitumor activity of Fab' and IgG-anti-CD22 immunotoxins in disseminated human B lymphoma grown in mice with severe combined immunodeficiency disease: effect on tumor cells in extranodal sites Cancer Research 51(21): 5876-5880
Sica, G.; Lama, G.; Iacopino, F.; Angelucći, C.; Della Cuna, G.R.; Marchetti, P. 1991: Antitumor effect of lonidamine alone or combined with tamoxifen or medroxyprogesterone acetate in breast cancer cells Anticancer Research 11(6): 2099-2102
Yoshida, Y.; Tasaki, K.; Kimurai, M.; Takenaga, K.; Yamamoto, H.; Yamaguchi, T.; Saisho, H.; Sakiyama, S.; Tagawa, M. 1998: Antitumor effect of human pancreatic cancer cells transduced with cytokine genes which activate Th1 helper T cells Anticancer Research 18(1a): 333-335
Izdebska, M.; Natorska-Chomicka, D.; Jagiełło-Wójtowicz, E. 2014: Preliminary studies evaluating cytotoxic effect of combined treatment with methotrexate and simvastatin on green monkey kidney cells Acta Poloniae Pharmaceutica 71(3): 515-520
Lisignoli, G.; Toneguzzi, S.; Monaco, M.C.; Tomassetti, M.; Bertollini, V.; Lavaroni, S.; Degrassi, A.; Facchini, A. 1995: Effect of stromal cells from human lymph nodes on the growth of osteosarcoma cell lines Bollettino della Societa Italiana di Biologia Sperimentale 71(9-10): 263-267
Wang, L.; Cheng, C.; Zhao, H.; Cui, H. 2012: Anti-tumor effect of phytic acid on human osteosarcoma U2OS cells in vitro Wei Sheng Yan Jiu 41(6): 943-946
Siveski-Iliskovic, N.; Hill, M.; Chow, D.A.; Singal, P.K. 1995: Probucol protects against adriamycin cardiomyopathy without interfering with its antitumor effect Circulation 91(1): 10-15
Bacci, G.; Picci, P.; Ruggieri, P.; Avella, M.; Mercuri, M.; Capanna, R.; Biagini, R.; Tienghi, C.; Mancini, A.; Brach del Prever, A. 1991: Neoadjuvant chemotherapy for the treatment of osteosarcoma of the limbs. Preliminary results in 100 patients treated preoperatively with high doses of methotrexate I.v. followed by cisplatin (i.a.) and adriamycin La Chirurgia Degli Organi di Movimento 76(1): 1-16
Gautam, S.; Chikkala, N.; Ganapathi, R. 1992: Immunomodulation by adriamycin - effect on the production of cytotoxic and inflammatory antitumor immune-responses International Journal of Oncology 1(7): 799-805
Kano, Y.; Ohnuma, T.; Okano, T.; Holland, J.F. 1988: Effects of vincristine in combination with methotrexate and other antitumor agents in human acute lymphoblastic leukemia cells in culture Cancer Research 48(2): 351-356
Papavasiliou, C.; Pappas, J.; Aravantinos, D.; Kaskarelis, D. 1978: Treatment of cervical carcinoma with adriamycin combined with methotrexate Cancer Treatment Reports 62(9): 1387-1388
Wand, H.; Rieche, K.; Rudolf, J.; Pescheck, C.; Grünhagen, H.; Binder, M.; Kleinwächter, A. 1976: Cellelectrophoretic studies of the effect of methylglyoxal-bis-guanylhydrazone on blood cells of tumour patients Archiv für Geschwulstforschung 46(4): 304-310
Zhang, J.; Mizoi, T.; Harada, N.; Shiiba, K-Ichi.; Miyagawa, K.; Matsuno, S.; Sasaki, I. 2003: Thymidine phosphorylase expressed in macrophages enhances antitumor effect of 5'-deoxy-5-fluorouridine on human colorectal carcinoma cells Anticancer Research 23(1a): 323-329
Chen, Y.; Wang, S.; Geng, B.; Yi, Z. 2018: Pelargonidin induces antitumor effects in human osteosarcoma cells via autophagy induction, loss of mitochondrial membrane potential, G2/M cell cycle arrest and downregulation of PI3K/AKT signalling pathway Journal of BUON: Official Journal of the Balkan Union of Oncology 23(3): 735-740
Nakajima, T.; Masuda, H.; Okamoto, T.; Watanabe, M.; Yokoyama, K.; Yamada, N.; Tsukagoshi, S.; Taguchi, T. 1991: Combined effect of HO-221 with various antitumor agents against L 1210 leukemia Gan to Kagaku Ryoho. Cancer and ChemoTherapy 18(4): 555-562
Niitsu, Y.; Ishigaki, S.; Kogawa, K.; Mogi, Y.; Watanabe, N.; Kohgo, Y.; Urushizaki, I. 1988: Effect of combined administration of a prostacyclin analogue and adriamycin against the artificial metastasis of Meth A cell Invasion and Metastasis 8(1): 57-72
Mordoh, J.; Chacón, R.D.; Filmus, J. 1981: Isolation of tumor cells from patients with osteosarcoma and analysis of their sensitivity to methotrexate Cancer Research 41(9 Part 1): 3621-3628
Hoshino, M.; Koyama, Y.; Sugano, K.; Kanno, M.; Satou, N.; Abe, R. 1989: Enhanced effect of hepatic arterial infused anticancer drugs on rabbit VX-2 carcinoma by means of combination with Lipiodol. Adriamycin versus Lipiodol adriamycin sandwich method and adriamycin suspended in a Lipiodol Gan to Kagaku Ryoho. Cancer and ChemoTherapy 16(8 Part 2): 2810-2813