Pharmacological analysis of the pendular movements appearing during calcium blocking of peristalsis in the isolated guinea pig ileum
Beleslin, D.
Comptes Rendus des Seances de la Societe de Biologie et de ses Filiales 171(4): 746-750
1977
ISSN/ISBN: 0037-9026 PMID: 145274 Document Number: 123930
Calcium chloride acting from the serosal surface blocked the peristaltic reflex and at the same time, after about 30 minutes, evoked pendulum type of activity in the longitudinal muscle of the guinea-pig isolated ileum, subjected to constant intraluminal pressure. Hexamethonium, tetraethylammonium, morphine, methadone and atropine blocked, while, neostigmine potentiated the pendulum movements evoked by calcium chloride. In the Magnus preparation of the guinea-pig isolated ileum calcium chloride also caused pendulum type of activity. From these experiments it is concluded that calcium chloride evoked pendular movements by stimulating the postganglionic cholinergic nerves in the longitudinal muscle of the guinea-pig isolated ileum.