Drug activation by gamma irradiation: a new direction for molecular design. Part I: In vitro and in vivo studies of a substituted polyaminoaryl nitrile
Zweig, J.I.; Herz, M.L.; Mclaughlin, W.L.; Bhuthimethee, V.
Cancer Treatment Reports 61(3): 419-423
1977
ISSN/ISBN: 0361-5960 PMID: 872141 Document Number: 123748
The disodium salt of 4-diethyl aminophenyl-4',4"-bis(3-sulfobenzyl ethylaminophenyl)acetonitrile was made and studied. It released cyanide linearly with exposure to ionizing radiation. When administered i.p. to mice, it was absorbed in significant amounts and retained its ability to cleave on irradiation. Based on this, evidence was gathered and it was proposed that it is feasible to design a non-toxic compound which when exposed to ionizing radiation would yield predictable reactive end products that would remain localized and augment the effects of irradiation on a neoplasm.