Minimizing the potential for metabolic activation as an integral part of drug design
Evans, D.C.; Baillie, T.A.
Current Opinion in Drug Discovery and Development 8(1): 44-50
2005
ISSN/ISBN: 1367-6733 PMID: 15679171 Document Number: 589276
The formation of drug-protein adducts carries a risk of clinical toxicities that may not be predicted by preclinical safety studies. The process of minimizing the potential for metabolic activation at the lead optimization stage could therefore be viewed as a step for building quality into future generations of drug products.
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