Metabolic activation and toxicology - some models of chemical protection against drug toxicity
Lesca, P.
Toxicological European Research. Recherche Europeenne en Toxicologie 3(3): 161-166
1981
ISSN/ISBN: 0249-6402 PMID: 7025349 Document Number: 182098
This article describes some examples concerning the mechanism involved in the drug toxicity mediated by the enzymes of metabolism. They concern the production of various reactive metabolites which strongly bind to biological macromolecules inducing different forms of toxicity (necrosis, mutations and cancers). Some recent data on the field of protection and prevention means against the hepatoxicity of carcinogenesis are described.