Recent studies on the metabolic activation of chemical carcinogens
Miller, J.A.
Cancer Research 54(7 Suppl): 1879s-1881s
1994
ISSN/ISBN: 0008-5472 PMID: 8137303 Document Number: 426742
Xenobiotics continue to be found that are metabolized in mammals to electrophilic reactants that form covalently bound adducts to cellular DNA leading to tumor formation. This discussion will be limited to the following two topics: sulfonation in chemical carcinogenesis and endogenous etheno adducts in DNA.