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Metabolic activation: a biological mechanism that augments the toxicity of xenobiotics

Valenzuela, A.

Revista Medica de Chile 118(9): 1028-1034

1990

ISSN/ISBN: 0034-9887
PMID: 2152733
Document Number: 358483
Metabolic changes sustained by foreign substances (biotransformation), xenobiotics, may not always lead to a decreased toxicity from these substances. Metabolic activation, a process that may increase toxicity and chemical reactivity of these substances, may occur at the first or second phase of biotransformation. Electrophiles of nucleophiles may be formed. Lipoperoxidation by free oxygen radicals may thus follow. Details of these processes are discussed in the paper.

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