Autoradiographic localization of prolactin receptors in 7,12-dimethylbnez[a]anthracene-induced rat mammary carcinoma
Costlow, M.E.; Mcguire, W.L.
Journal of the National Cancer Institute 58(4): 1173-1175
1977
ISSN/ISBN: 0027-8874 PMID: 191627 Document Number: 116788
Prolactin receptors were localized by autoradiography in 7,12-dimethylbenzovine prolactin. Specific prolactin binding was confined to tumor cells, and nonspecific binding was present in alveolar spaces and connective tissue. In some tumors, all cells contained receptors. In others, up to 1/2 the cells remained unlabeled. Variation in receptor content in DMBA induced mammary tumors may be caused by 2 populations of cells, one which contains receptors and another which possesses very few receptor sites or none at all.