Is there any association between elevated serum prolactin level and mammary adenocarcinoma induced by 7,12-dimethylbenz (alpha) anthracene
Feuer, G.; Kellen, J.A.; Kovacs, K.
Research Communications in Chemical Pathology and Pharmacology 11(3): 435-444
1975
ISSN/ISBN: 0034-5164 PMID: 807960 Document Number: 88084
The association between mammary carcinogenesis induced by 7,12-dimethylbenz(alpha)anthracene (DMBA) in the rat, the influence by manipulations of its hepatic metabolism and the secretion of prolactin has been investigated. Various test compounds: coumarin, 4-methylcoumarin, phenobarbital and CCl4 all elevated serum prolactin level, but only coumarin and 4-methylcoumarin reduced tumor incidence. These observations do not support the assumption that the suppression of DMBA-induced breast adenocarcinoma by coumarin and 4-methylcoumarin is mediated via prolactin.