Lack of correlation between the presence of estrogen receptor and histological type of mammary cancer induced by 7,12-dimethylbenz[alpha]anthracene
Nomura, Y.; Abe, Y.; Yamagata, J.; Takenaka, K.
Gan 66(6): 689-691
1975
ISSN/ISBN: 0016-450X PMID: 178560 Document Number: 92415
The relation between the histological type and thepresence of estrogen receptor or response to oophorectomy in the mammary cancers induced by 7,12-dimethylbanz(a)anthracene in Sprague-Dawley rats is discussed. 23 tumors were evaluated for histological classification. 4 were poorly differentiated (Type A), 16 were well-differentiated (Type B), none was atrophic (Type C), and 3 were secretory (Type D). Of the 4 Type A tumors, 3 had the estrogen receptor. Of the 16 Type B tumors, 10 were with the receptor. 3 secretory Type D tumors showed binding. The response to oophorectomy in each group showed no coorelation to the histological type of the tumor. However, there was a good correlation b etween the presence of estrogen receptor and response to oophorectomy in that 12 of 14 tumors that contained the estrogen receptor responded well. None of the 9 tumors that did not show the binding capacity had a good response. The biochemical feature of estrogen receptor has not been shown to exert influence on structural difference of these tumor cells.