Chloramphenicol and dextramycin, inhibitors of mammary carcinogenesis induced by 7,12-dimethylbenz (a) anthracene
Bogush, T.A.; Konopleva, I.A.; Shabad, L.M.
Biulleten' Eksperimental'noi Biologii i Meditsiny 88(11): 590-592
1979
ISSN/ISBN: 0365-9615 PMID: 120206 Document Number: 153983
In noninbred rats chloramphenicol and its optical isomer dextramycin diminished the blastomogenic effect of 7,12-dimethylbenz(a)anthracene on mammary glands. The protective effect was shown by a decreased tumor incidence at all periods of observation and an increase in the life span of rats and in the case of dextramycin this action consisted in a prolongation of the latent period of tumor emergence.
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