Reserve production of renin by glomerular mesangial cells following experimental decrease in renal circulation
Fedorov, V.I.; Perov, I.L.
Biulleten' Eksperimental'noi Biologii i Meditsiny 83(6): 656-659
1977
ISSN/ISBN: 0365-9615 PMID: 884289 Document Number: 115407
The aorta was partially constricted between the origins of the two renal arteries in rats. The renin activity was studied separately in the capillary parts of the isolated glomeruli and in their arterioles. The renin activity was found in the capillary parts of the glomeruli 3 to 4 weeks after the constriction. The rough and smooth endoplasmic reticulum and the Golgi complex of the mesangial cells were activated at this period. The authors consider these results as a confirmation of the hypothesis on the reserve renin production by mesangial cells under prolonged decrease of renal circulation.