Effects of a number of cytokines on the proliferation of mesangial cells and the production of extracellular matrix in anti-GBM nephritis
Ivanov, A.A.; Gladskikh, O.P.; Shilov, E.M.; Gitel', E.P.; Meshcheriakova, M.A.; Pal'tsev, M.A.
Vestnik Rossiiskoi Akademii Meditsinskikh Nauk 5: 56-59
1995
ISSN/ISBN: 0869-6047 PMID: 7626988 Document Number: 443166
The interaction of IL-1 and TNF alpha in the autolous phase of anti-GBM nephritis was studied. The influx of mononuclear leukocytes into the glomerulus and high cytokine levels induced a decrease in mesangial cell proliferation and an increase in extracellular matrix production. The methylprednisolone suppression of mononuclear leukocyte infiltration caused the autocine cytokine secretion of mesangial cells. Cyclophosphamide decreased cytokine production, but did not affect mononuclear leukocyte infiltration. The absence of mononuclear leukocytes in the site of the injury induced by imbalance between the synthesis and degradation of extracellular matrix components. The uncontrolled metabolism of the extracellular matrix may be induced glomerulosclerosis.