Renal reserve: a functional view of glomerular filtration rate

Bosch, J.P.

Seminars in Nephrology 15(5): 381-385

1995


ISSN/ISBN: 0270-9295
PMID: 8525139
Document Number: 7513
The hyperfiltration theory challenged the view that glomerular filtration rate is a fixed function as well as that there is a good correlation between GFR and renal parenchymal damage. Glomerular filtration rate is a dynamic parameter that is diet-dependent and can be altered by hemodynamic maneuvers. Therefore, it is not a good indicator of renal lesion. The renal reserve is an indicator of the workload per nephron and may be a useful parameter to assess the progression of renal disease in the presence of dietary or pharmacological intervention.

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Renal reserve: a functional view of glomerular filtration rate