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A new method for synthesis of some nucleoside 5'-phosphonate esters

Khropov, I.V.; Guliaev, N.N.; Severin, E.S.

Biokhimiia 42(10): 1742-1746

1977

ISSN/ISBN: 0320-9725
PMID: 922063
Document Number: 112674
A new method for synthesis of nucleoside-5'-phosphonates containing a reactive halogen atom in the phosphonate residue has been developed. In order to achieve selective inhibition of individual enzymes and to elucidate the structure of their active sites, the synthesis of 5-'chloromethyl-, 5'-(beta-bromoethyl)-and 5'-(N-chloroacetylaminomethyl)-phosphonate esters of adenosine and previously unknown analogous derivatives of uridine have been carried out. The method described may also be used to synthesize 5'-phosphonate esters of nucleosides, which contain radioactive labels.

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Venyaminova, A.G.; Repkova, M.N.; Maltseva, T.V. 1991: Preparative solid phase synthesis of a tetradecamer r(GAUUGAAAAUCCCC) by the H-phosphonate method using a 2'-O-tetrahydropyranyl protective group Nucleic Acids Symposium Series 24: 263
Somogyi, G.; Buchwald, P.; Bodor, N. 2004: Metabolic properties of phosphonate esters Die Pharmazie 59(5): 378-381
Fujii, M.; Nagai, H.; Sekine, M.; Hata, T. 1986: The phosphorothioite method. Synthesis of deoxyoligonucleotides on polymer supports by using nucleoside phosphorothioites Nucleic Acids Symposium Series 17: 77-80
Cieślak, J.; Sobkowski, M.; Jankowska, J.; Wenska, M.; Szymczak, M.; Imiolczyk, B.; Zagórowska, I.; Shugar, D.; Stawiński, J.; Kraszewski, A. 2001: Nucleoside phosphate analogues of biological interest, and their synthesis via aryl nucleoside H-phosphonates as intermediates Acta Biochimica Polonica 48(2): 429-442
Dubey IYa; Lyapina, T.V.; Fedoryak, D.M. 1991: H-phosphonate oligonucleotide synthesis in solution Nucleic Acids Symposium Series 24: 270
Mcelhinney, R.S.; Mccormick, J.E.; Bibby, M.C.; Double, J.A.; Atassi, G.; Dumont, P.; Pratesi, G.; Radacic, M. 1989: Nucleoside analogues. 9. Seco-nucleoside analogues of some 5-fluorouracil/nitrosourea molecular combinations having uracil as base: synthesis and anti-tumour activity Anti-Cancer Drug Design 4(3): 191-207
Kurkin, A.; Coulagina, M.; Batchikova, N.; Smirnov, V.; Lutsenko, S.; Azhayev, A. 1991: Recombinant human interleukin. 4. H-phosphonate synthesis of structural gene, expression in E.coli, isolation and study of chemical and biological properties Nucleic Acids Symposium Series 24: 294
Shirokova, E.A.; Shipitsyn, A.V.; Kuznetsova, E.V.; Viktorova, L.S.; Kraevskiĭ, A.A. 1993: 5'-S-nucleoside triphosphates. Synthesis and substrate properties in tests with DNA polymerases Bioorganicheskaia Khimiia 19(12): 1226-1233
Shimidzu, T.; Maikuma, S.; Yamana, K.; Yamoto, S.; Honda, K. 1985: A rapid synthesis of a DNA fragment using an unprotected nucleoside and a phosphine derivative Nucleic Acids Symposium Series 16: 149-152
Li, S.W.; Sun, H.L.; Lu, X.J.; Zhang, S.Y.; Lu, F.L.; Dai, J.Y.; Xu, Y.B. 1981: Synthesis of cephalotaxine esters and their antitumor activity Yao Xue Xue Bao 16(11): 821-827
Antrazhev, A.M.; Diatkina, N.B.; Kraevskiĭ, A.A.; Kukhanova, M.K.; Chidzhavadze, Z.G. 1987: Ability of 3'-substituted nucleoside phosphothioates to terminate DNA synthesis catalyzed by various DNA-polymerases Bioorganicheskaia Khimiia 13(8): 1045-1052
Desai, N.C.; Undavia, N.K.; Trivedi, P.B.; Dave, D.; Vyas, G.D. 1998: Synthesis and anti-HIV activity of some non-nucleoside 2,3-disubstituted quinazoline derivatives (Part-V) Indian Journal of Experimental Biology 36(12): 1280-1283
Ubukata, M.; Osada, H.; Isono, K. 1985: Synthesis and biological activity of nucleoside antibiotics, ascamycin and its amino acid analogs Nucleic Acids Symposium Series 16: 81-83
Pavlov, A.I.; Olsuf'eva, E.N.; Berdnikova, T.F.; Rozynov, B.V.; Aleksandrova, L.G.; Malkova, I.V.; Preobrazhenskaia, M.N. 1991: Synthesis and antibacterial activity of eremomycin esters through the carboxyl group Bioorganicheskaia Khimiia 17(6): 849-854
Dal Pozzo, A.; Acquasaliente, M.; Donzelli, G.; Delor, F.; Ferruti, P. 1986: Synthesis and antimicrobial properties of new aroyl-acrylic esters of polyethylene glycols Il Farmaco; Edizione Scientifica 41(8): 622-629
Duro, F.; Vittorio, F. 1978: Synthesis and pharmacological activity of esters and amides of 4-phenylcoumarin-3-carboxylic acid Il Farmaco; Edizione Scientifica 33(1): 73-77
Ye, X-rong.; Chai, Y-hai.; Li, X-nan.; Wu, K-mei. 2004: Studies on the synthesis and antitumor activity of the derivatives of cephalotaxine alkaloid esters Yao Xue Xue Bao 39(6): 429-433
Böttcher, M.; Henklein, P.; Hoffmann, K.; Heder, G.; Siems, W.E.; Niedrich, H. 1986: Synthesis of n-substituted amino acid-p-nitrobenzyl esters as potential ACE inhibitors Die Pharmazie 41(2): 140
Görlitzer, K.; Trittmacher, J.; Jones, P.G. 2002: Synthesis, structure and stability of 4-aryl-4H-pyran-3,5-dicarboxylic acid esters Die Pharmazie 57(8): 523-529
Oogo, Y.; Ono, A.; Tate, S.; Ono, A.; Kainosho, M. 1997: Synthesis of stereoselectively 5'-monodeuterated nucleoside with defined S/R-ratios. An application to the assignment of 5'-methylene signals of DNA oligomers Nucleic Acids Symposium Series 37: 35-36