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Different tissue uptake after administration of proline and hydroxyproline in neonatal piglets

Bengtsson, G.; Hakkarainen, J.

Acta Veterinaria Scandinavica 18(4): 501-508

1977

ISSN/ISBN: 0044-605X
PMID: 596329
Document Number: 112007
Using whole body autoradiography and impulse counting technique, distribution of i/m administered 14C-DL-hydroxyproline and 14C-L-proline in newborn piglets was compared. The main excretion route of hydroxyproline was the kidney. Hydroxyproline or its metabolic products were excreted at a different rate by the liver than was proline. Skeletal muscles and myocardium showed a lowered ratio of proline to hydroxyproline. A difference in favour of hydroxyproline in passing the blood-brain barrier was shown. Contrary to proline, hydroxyproline yielded a low 14C level in the skeletal tissues. The possibilities of an incomplete hydroxylation of proline as an aetiological factor in the origin of skeletal disorders are discussed.

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