State of phagocytic immunity in white mice treated with doxycycline and pentoxyl for experimental staphylococcal sepsis
Manukova, M.A.
Antibiotiki 21(12): 1098-1104
1976
ISSN/ISBN: 0003-5637 PMID: 1020944 Document Number: 106318
When albino mice with experimental staphylococcal sepsis were treated by doxycycline for 10 days, it was noted that the antibiotic had an inhibitory effect on the absorbing capacity of the peritoneal leucocytes with respect to Staph aureus. The decreased digesting capacity of the leucocytes was observed only during the first 5 days from the moment of infection and treatment. The combined use of doxycycline and pentoxyl stimulated the activity and intensity of phagocytosis. The activity values of completed phagocytosis did not change, while the coefficient of the phagocytosis completeness increased as compared to the same values in the animal group treated with doxycycline alone.