Myocardial metabolism of spontaneously hypertensive rat
Saito, N.; Anazawa, S.; Kogure, T.; Kosuga, M.; Nagano, M.
Recent Advances in Studies on Cardiac Structure and Metabolism 12: 373-381
1976
ISSN/ISBN: 0363-5872 PMID: 1031989 Document Number: 105378
Oxidative phosphorylation of myocardial mitochondria isolated from spontaneously hypertensive rats (SHR) was determined polarographically. The concentrations of high-energy phosphate compounds, the concentrations of intermediate metabolites, and the activities of the enzymes within the metabolic systems of glycolysis, the pentose phosphate (PPh) cycle, and the tricarboxylic acid (TCA) cycle of the myocardium of SHR were determined. The gradual development of cardiac hypertrophy was observed in SHR in comparison with normotensive Wistar rats. There were no significant differences in the function of oxidative phosphorylation of the mitochondria, in concentrations of high-energy phosphate compounds and carbohydrate metabolites, or in activities of glycolytic enzymes between SHR and normotensive Wistar rats.